Absolutely. Takes the most simple-to-render website and makes it unusable for an entire class of device, just by adding:

    <meta name="viewport"
          content="width=device-width,
                   initial-scale=1,
                   maximum-scale=1,
                   user-scalable=no">

(wrapped for your viewing pleasure)

Why would you ever do this on a page designed for readability?

And one finger zoom on Chrome mobile. Any zoom really.