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> We’re nearing the utopic phase for this drug (if we aren’t already there)

GLP-1 increasingly looks like a vitamin.

It is "essential to [humans] in small quantities for proper metabolic function" [1]. But what our body produces gets eliminated in minutes [2]. Not everyone needs supplementation and too much can be harmful. But a deficit results in ultimately-fatal chronic conditions.

[1] https://en.wikipedia.org/wiki/Vitamin

[2] https://en.wikipedia.org/wiki/Glucagon-like_peptide-1



Good thing they're not GLP-1. They're GLP-1 agonists. At least in semaglutide's case their half-life is 1 week


> Good thing they're not GLP-1. They're GLP-1 agonists

Sure, which is why I say looks like, not may be. If calcitrol were eliminated like GLP-1, a drug that activated the VDR would be beneficial to those with a deficiency [1].

[1] https://en.wikipedia.org/wiki/Vitamin_D_receptor




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