This reminds me of spice. Synthetic cannabinoids started in 00s as a legal alternative to weed, but in a span of just around 10 years evolved into one of the most frightening drugs out there.
JWH-018, the first very widely available one seemed safer (based on my own limited research) than those that followed, but was banned. it's the same thing every time. chemical gets banned, more dangerous but legal chemical takes it's place, cycle continues.