Which I find is actually quite problematic; "make install" by default puts things into /usr/local, and I would prefer to distinguish between things I've installed and things ports have installed. (Specifically, I need to build my own mplayer, but I also need the ports version installed as some other ports depend on it).
Feel free to change the prefix passed to the packages you install by hand. /usr/local is the default used by almost all packages I am familiar with, if for example you want /opt you have to modify that yourself.
See man hier [1].
For example, on a FreeBSD install, it is perfectly safe to rm -rf /usr/local/. Your system will still boot without issues.
[1] http://www.freebsd.org/cgi/man.cgi?query=hier&apropos=0&...