Maybe I misread your post if your claim was that not every mRNA strand enter the cell. apologies.
That said, this type of mass analysis is deeply flawed.
It ignores the difference between mRNA weight and spike protein weight. I believe this lowers the ratio as the mRNA is more massive than the spike protein encoded.
On the other side, it ignores the number of of times each mRNA strand is transcribed to protein. It also ignores the adjuvant effect of the lipid nanoparticle, which amplifies the immunogenicity of the protein mass.
That said, I think the entire discussion of mass is a gross oversimplification to the question of comparing possible long covid autoimmune conditions between vaccination and natural infection. There is soo much more going on: rates of immune response, differences in intensity, differences in immunogen proteins, ectara.
Overall, I think it is an open question. It seems plausible that vaccination could cause long covid in some cases, especially given that it has been show capable of causing autoimmune multisystem inflammatory syndrome. It is also plausible that it could be used to address long covid, by attenuating the immune response or some other mechanism.
I'm not doing mass analysis. That's why I divided by the molar mass of the mRNA strand. I'm comparing the number of virions to the number of mRNA strands. I already corrected for what you mentioned.
> It also ignores the adjuvant effect of the lipid nanoparticle, which amplifies the immunogenicity of the protein mass.
If you think long covid is caused by the immune reaction, this is all moot, as I said in the original post. It's very possible longcovid is autoimmune, but it's possible it's not.
I saw mrna strand vs spikes, so this at least leaves out transcription cycles. I point this out now not to be argumentative, but simply because I'm curious. My understanding was that it was not one to one.
Also for the sake of curiosity, what are the non immunogenic theories? Some sort of persistent damage from the spike count?
Yes, I also took into account transcription cycles - it would take 1000+ transcriptions per mRNA strand to break even.
But yes, persistent damage from spikes is a non immunogenic theory. There are also theories of persistent infection and viral damage to various organs, as well as exhaustion of the immune system, etc..., and of course it could be a sum of any.
That said, this type of mass analysis is deeply flawed. It ignores the difference between mRNA weight and spike protein weight. I believe this lowers the ratio as the mRNA is more massive than the spike protein encoded. On the other side, it ignores the number of of times each mRNA strand is transcribed to protein. It also ignores the adjuvant effect of the lipid nanoparticle, which amplifies the immunogenicity of the protein mass.
That said, I think the entire discussion of mass is a gross oversimplification to the question of comparing possible long covid autoimmune conditions between vaccination and natural infection. There is soo much more going on: rates of immune response, differences in intensity, differences in immunogen proteins, ectara.
Overall, I think it is an open question. It seems plausible that vaccination could cause long covid in some cases, especially given that it has been show capable of causing autoimmune multisystem inflammatory syndrome. It is also plausible that it could be used to address long covid, by attenuating the immune response or some other mechanism.